A plaque remaining from the Big Apple Night Club at West 135th Street and Seventh Avenue in Harlem.

Above, a 1934 plaque from the Big Apple Night Club at West 135th Street and Seventh Avenue in Harlem. Discarded as trash in 2006. Now a Popeye's fast food restaurant on Google Maps.

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Entry from April 22, 2020
“My body only fights off illness on Saturday and Sunday. I have a weekend immune system”

"Weakened immune system” shouldn’t be confused with “weekend immune system,” but there are jokes.

“I’m intrigued by the ‘weekend immune system’. Does that mean it only works on Saturdays and Sundays?” was posted on the newsgroup milw.jobs on June 28, 2004. “My body only fights off illness on Saturday and Sunday. I have a weekend immune system” was posted on Reddit—Jokes on April 22, 2020.


Google Groups: milw.jobs
Last Ditch Effort
Jay Cunnington
6/28/04
I’m intrigued by the “weekend immune system”. Does that mean it only works on Saturdays and Sundays?

Twitter
Gilbert Goldbug
@ohmygil
@nerdist i came down with a cold on Saturday. Curse my weekend immune system.
12:23 PM · Mar 29, 2009·Twitter SMS

Twitter
Ample Artistry
@ampleartistry
Did you hear about the man who got sick Monday through Friday? He had a weekend immune system #immunesystem #jokes
7:46 AM · Mar 5, 2014·Twitter Web Client

Twitter
Galaxy Mermaid
@TheXPLaura
I only get ill Monday through Friday due to my weekend immune system.
1:38 PM · Jul 23, 2014·Twitter for iPhone

Twitter
NorthernLine
@NrthrnLine
Drinking heavily on Fridays and Saturdays leaves you with a weekend immune system. #1Pun
8:01 AM · Apr 29, 2015·Twitter for iPhone

Twitter
Dave Methvin
@davemethvin
I seem to catch more colds during the week but get better on Saturday or Sunday. Does that mean I have a weekend immune system?
11:19 PM · Sep 22, 2015·TweetDeck

Twitter
Peter Brown
@beerlington
If you only get sick during the week, you might have a weekend immune system. boom.
2:29 PM · Dec 12, 2016·Twitter Web Client

Twitter
Michael’s Twiter.com Page
@ErrorAustralis
Nothing bad happens to me on Saturday and Sunday. Because I have a weekend immune system! Ha ha ha! Ha.
8:23 PM · Jun 3, 2017·Twitter for iPhone

Twitter
Joseph Gauci
@RogueGauci
What do people with a weekend immune system do Monday to Friday?
10:52 AM · Sep 14, 2017·Twitter Web Client

Twitter
Tom Schmit
@Educ_in_Latvia
Is a weekend immune system one that only works on Saturdays and Sundays?
10:39 PM · Dec 19, 2019·Twitter Web App

Twitter
Ahmed Zaheer
@ahmedalzaheer
My doctor told me to ignore quarantine on Saturdays and Sundays because I have a weekend immune system
3:14 AM · Mar 18, 2020·Twitter for iPhone

Twitter
Imtiaz Mahmood
@ImtiazMadmood
According to my doctor it should be okay for me to ignore social distancing on Saturdays and Sundays.
He said I have a weekend immune system.
4:43 AM · Mar 18, 2020·Twitter Web App

Reddit—Jokes
Posted by u/the_narrow_road April 22, 2020
My body only fights off illness on Saturday and Sunday
I have a weekend immune system

Posted by Barry Popik
New York CityTime/Weather • Wednesday, April 22, 2020 • Permalink